On 8 April, RFLab has opened the doors of its laboratory to high school students. The operation “Fête de la science” gives annual opportunity for the public to come discover the world of biomedical research and exchange with researchers, engineers and technicians on their job in order to encourage vocations. A window on the usually impenetrable places! The program was made of mini-lectures, direct exchanges, experimental workshops …
In the context of the FP7 international training network iMODE-CKD (http://www.imodeckd.org/) we organized a workshop/seminar open to the scientific community entitled « Systems Biology approaches, omics integration » on Friday afternoon October 2, 2015 and Saturday morning October 3, 2015. Presentations included topics on different omics technologies, databases, data, examples of systems biology in various fields (cancer, kidney disease) and implementation by leaders in the field. Of course we not only listened to the fabulous talks but also enjoyed a lot of good (scientific) time around local food specialities…
Jean-Loup Bascands and Stanislas Faguer wearing the official gown as they were members of the jury of the thesis for a doctorate in Medicine of David Milongo (September 17, 2015). Pretransplant urinary proteome analysis does not predict development of chronic kidney disease after liver transplantation. Milongo D, Bascands JL, Huart A, Esposito L, Breuil B, Moulos P, Siwy J, Ramírez-Torres A, Ribes D, Lavayssière L, Del Bello A, Muscari F, Alric L, Bureau C, Rostaing L, Schanstra JP, Kamar N. Liver Int. 2014. [Read] Congratulations David!
Unmasking Silent Endothelial Activation in the Cardiovascular System Using Molecular Magnetic Resonance Imaging. Belliere J, Martinez de Lizarrondo S, Choudhury RP, Quenault A, Le Béhot A, Delage C, Chauveau D, Schanstra JP, Bascands JL, Vivien D, Gauberti M. Theranostics. 2015. [Read] Endothelial activation is a hallmark of cardiovascular diseases, acting either as a cause or a consequence of organ injury. To date, we lack suitable methods to measure endothelial activation in vivo. In the present study, we developed a magnetic resonance imaging (MRI) method allowing non-invasive endothelial activation mapping in the vasculature of the main organs affected during cardiovascular diseases. In clinically relevant contexts inRead More →
Prof Stéphane Decramer gave an invited lecture (on Friday, September 4th) at the ESPN in Brussels on the role of HNFbeta in kidney disease and other organs.
New insights in molecular mechanisms involved in chronic kidney disease using high-resolution plasma proteome analysis. Glorieux G, Mullen W, Duranton F, Filip S, Gayrard N, Husi H, Schepers E, Neirynck N, Schanstra JP, Jankowski J, Mischak H, Argilés À, Vanholder R, Vlahou A, Klein J. Nephrol Dial Transplant. 2015 Jul 9. [Read] The reduced glomerular filtration rate in the advanced stages of chronic kidney disease (CKD) leads to plasma accumulation of uraemic retention solutes including proteins. It has been hypothesized that these changes may, at least in part, be responsible for CKD-associated morbidity and mortality. However, most studies focused on the role of individual proteins,Read More →
Omics integration and Systems biology play a key role in biology research due to major advances in high-throughput technologies and an exponential increase in available experimental data. In the context of the FP7 international training network iMODE-CKD, the Renal Fibrosis Laboratory is organizing a workshop on this topic on Friday afternoon October 2 and Saturday morning October 3, 2015. European leaders in the field will present their activity and latest methodological and technical developments on different omics technologies, databases, data, examples of systems biology in various fields (cancer, kidney disease) and implementation. The detailed program can be found below. Open toRead More →
PLoS One. 2015 Jul 6;10(7):e0131416. Tubular epithelial cells in the kidney are continuously exposed to urinary fluid shear stress (FSS) generated by urine movement and recent in vitro studies suggest that changes of FSS could contribute to kidney injury. However it is unclear whether FSS alters the epithelial characteristics of the renal tubule. Here, we evaluated in vitro and in vivo the influence of FSS on epithelial characteristics of renal proximal tubular cells taking the organization of junctional complexes and the presence of the primary cilium as markers of epithelial phenotype. Human tubular cells (HK-2) were subjected to FSS (0.5 Pa) for 48h. ControlRead More →
The RF-lab is moving from the ground to the 4th floor. Science will be a little slow for the coming weeks. Sorry about that. But admire the “view”.
The RF-lab is in London represented by one of our PhD students: Theofilos Papadopoulos. As you can see he is clearly very proud to be there standing in front of his first poster! This is the 52nd congress of ERA-EDTA, which is the largest kidney meeting in Europe taking place once a year. It will be a meeting of outstanding scientific interest and quality in the world-famous city of London. The meeting will allow for major coverage of the main clinical areas of interest for practicing nephrologists, and it will also feature cutting-edge scientific discoveries. Translational research has as usual a prominent part in the programme, and specialRead More →
