The prevalence of diabetes continues to increase worldwide and premature mortality in diabetic patients largely is related to macro- and microvascular complications. One of these major microvascular complications is diabetic nephropathy, which significantly amplifies mortality in the diabetic population. Despite efficient therapies to control glycaemia and blood pressure, still 25-30% of the patients develop diabetic nephropathy and macrovascular complications. There is thus ample space to improve treatment of these complications but this needs better understanding of the mechanisms involved.
We believe that one of the major causes of this lack of knowledge is the absence of an animal model cumulating both micro- and macrovascular lesions. Therefore, by using a new animal model of type I diabetes mimicking human vascular complications in diabetes: diabetic nephropathy as the prototypic microvascular lesion and atherosclerosis, our project aims to better understand the development and progression of DN by the in-depth characterisation of this new animal model.