LPA in CKD! Latest paper in J Physiol Biochem !

j-physiol-biochem

Increased urinary lysophosphatidic acid in mouse with subtotal nephrectomy: potential involvement in chronic kidney disease. Mirzoyan K, Baïotto A, Dupuy A, Marsal D, Denis C, Vinel C, Sicard P, Bertrand-Michel J, Bascands JL, Schanstra JP, Klein J, Saulnier-Blache JS. J Physiol Biochem. 2016 Sep 17. PMID: 27637780

 jpb-koryun-1

Check out the first paper of one of our PhD students Koryun Mirzoyan. He studied LPA in a chronic kidney disease mouse model (subtotal nephrectomy, SNX).

It was concluded that SNx increases urinary LPA through a mechanism that could involve co-excretion of plasma LPA with albumin associated with a reduction of its catabolism in the kidney.

jpb-koryun-2

If our hypothesis is correct, the enzymes involved in the metabolism of LPA might represent potential targets for the treatment of CKD.

Congrats to Kuryon!