Increased urinary lysophosphatidic acid in mouse with subtotal nephrectomy: potential involvement in chronic kidney disease. Mirzoyan K, Baïotto A, Dupuy A, Marsal D, Denis C, Vinel C, Sicard P, Bertrand-Michel J, Bascands JL, Schanstra JP, Klein J, Saulnier-Blache JS. J Physiol Biochem. 2016 Sep 17. PMID: 27637780
Check out the first paper of one of our PhD students Koryun Mirzoyan. He studied LPA in a chronic kidney disease mouse model (subtotal nephrectomy, SNX).
It was concluded that SNx increases urinary LPA through a mechanism that could involve co-excretion of plasma LPA with albumin associated with a reduction of its catabolism in the kidney.
If our hypothesis is correct, the enzymes involved in the metabolism of LPA might represent potential targets for the treatment of CKD.
Congrats to Kuryon!