UUO renal fibrosis model
This model is induced in mice or rats by unilateral ureteral ligation (UUO) of the left ureter. The animals rapidly develop, within a few days, severe tubulo-interstitial renal fibrosis with an inflammatory cell infiltrate in the affected kidney. This is an ideal “go or no-go” model to test the potential anti-fibrotic activity of (new) compounds.
SNX renal fibrosis model
This model consists at reducing the renal mass by 83%. This induces hyperfiltration and induces over a period of around 6 months significant fibrotic lesions in mice (C57bl/6j). In rats the model is somewhat faster as it induces renal fibrosis in 3 months. This is thus a more chronic model of the development of fibrosis somewhat closer to what is observed in humans.
Schanstra, J. P., Bachvarova, M., Neau, E., Bascands, J. L. and Bachvarov, D., Gene expression profiling in the remnant kidney model of wild type and kinin B1 and B2 receptor knockout mice. Kidney Int 2007