Colette Denis


PhD, Associate professor, Principal investigator


Road walked on:
Colette Denis received her PhD from the University Paul Sabatier, Toulouse, France, in 1985 and was recruited as an Associate Professor at University Paul Sabatier in 1988. From 1983 to 1990 she worked on the regulation of glycolysis in intestinal adenocarcinoma cells, and from 1990 to 2004 she specialized in molecular pharmacology. Since 2015, Colette Denis is a principal investigator at the Renal Fibrosis Lab, INSERM U1048.

Main domains of expertise:
Pharmacology, Efficacy of biased ligands, Cellular biology, Plasma /urine biochemistry

Selected Publications:
Dual agonist occupancy of AT1-R-α2C-AR heterodimers results in atypical Gs-PKA signaling. Bellot M, Galandrin S, Boularan C, Matthies HJ, Despas F, Denis C, Javitch J, Mazères S, Sanni SJ, Pons V, Seguelas MH, Hansen JL, Pathak A, Galli A, Sénard JM, Galés C. Nat Chem Biol. 2015, 11, 271-281. [Read]

Delineating the complexity of biased and full agonism reveals the existence of a new distinct active AT1 receptor entity. A. Saulière, M. Bellot, H. Paris, C. Denis, F. Finana, J. T. Hansen, M.F. Altié, M.H. Seguelas, J.L. Hansen, J.M. Sénard & C. Galés. Nat. Chem. Biol. 2012, 8, 622-30. [Read]

Probing heterotrimeric G protein activation: applications to biased ligands. C. Denis, A. Saulière, S. Galandrin, JM Senard & C. Galés. Curr. Pharm. Des. 2012, 18, 128-44. [Read]

Interest of alpha2-adrenergic agonists and antagonists in clinical practice: background, facts and perspectives. P.A. Crassous, C. Denis, H. Paris & J.M. Senard. Curr. Top. Med. Chem. 2007, 7, 187-94. [Read]

Alpha2-adrenoceptors regulate proliferation of human intestinal epithelial cells. S. Schaak, D. Cussac, C. Cayla, J.C. Ddevedjian, R. Guyot, H. Paris & C. Denis. Gut, 2000, 47, 242-250. [Read]