Jean Sébastien Saulnier-Blache


PhD, Director of research, Principal investigator


Road walked on:
Jean Sébastien Saulnier-Blache received his PhD from the University Paul Sabatier, Toulouse, France, in 1990. He was recruited at INSERM as a researcher in 1992 and promoted as director of research in 2005. From 1992 to 1994 he worked in the field of molecular biology at the University of South Carolina, Charleston, SC, USA. From 1994 to 2014 he worked in the field of Obesity and Diabetes at INSERM Toulouse. Since 2014, Jean Sébastien Saulnier-Blache is a principal investigator at the Renal Fibrosis Lab, INSERM U1048.

Main domains of expertise:
Cellular biology, Clinical lipidomics, Diabetic nephropathy, Lysophosphatidic acid, Renal fibrosis mechanisms

Selected Publications:
Pro-fibrotic activity of lysophosphatidic acid in adipose tissue: in vivo and in vitro evidence. Rancoule C, Viaud M, Gres S, Viguerie N, Decaunes P, Bouloumié A, Langin D, Bascands JL, Valet P, Saulnier-Blache JS. Biochim Biophys Acta. 2014 Jan;1841(1):88-96. [Read]

Lysophosphatidic acid impairs glucose homeostasis and inhibits insulin secretion in high-fat diet obese mice. Rancoule C, Attané C, Grès S, Fournel A, Dusaulcy R, Bertrand C, Vinel C, Tréguer K, Prentki M, Valet P, Saulnier-Blache JS. Diabetologia. 2013 Jun;56(6):1394-402. [Read]

Adipose-specific disruption of autotaxin enhances nutritional fattening and reduces plasma lysophosphatidic acid. Dusaulcy R, Rancoule C, Grès S, Wanecq E, Colom A, Guigné C, van Meeteren LA, Moolenaar WH, Valet P, Saulnier-Blache JS. J Lipid Res. 2011 Jun;52(6):1247-55. [Read]

LPA1 receptor activation promotes renal interstitial fibrosis. Pradère JP, Klein J, Grès S, Guigné C, Neau E, Valet P, Calise D, Chun J, Bascands JL, Saulnier-Blache JS, Schanstra JP. J Am Soc Nephrol. 2007 Dec;18(12):3110-8. [Read]

Potential involvement of adipocyte insulin resistance in obesity-associated up-regulation of adipocyte lysophospholipase D/autotaxin expression. Boucher J, Quilliot D, Pradères JP, Simon MF, Grès S, Guigné C, Prévot D, Ferry G, Boutin JA, Carpéné C, Valet P, Saulnier-Blache JS. Diabetologia. 2005 Mar;48(3):569-77. [Read]