Together with partners from Spain, Germany and the CEA in Paris, the RF-lab and the Toulouse hospital obtained a European grant for joint-research for implementation of Personalized Medicine in acute kidney disease. In our lab the project is coordinated by Stanislas Faguer, Julie Klein and Joost Schanstra.
The project includes research involving >1600 patients scheduled for cardiac surgery and at risk for acute kidney injury and development of novel treatments based on systems biology.
Here the official announcement of the study:
Acute kidney injury (AKI) kills 2 million people every year. In AKI, kidney function fails suddenly and may later recover spontaneously. However there is no treatment that accelerates recovery and patients may require replacement of renal function by dialysis.
Kidney Attack aims to change this status quo by innovative and smart combination of scientific literature, preclinical and clinical studies that explore multiple markers (i.e. systems biology, omics) to propose early personalized detection of AKI and novel treatments.
i) We will move from a single marker of early AKI to multiple markers that better capture the complexity of human disease
ii) We will develop a humanized version of this multiple marker panel
iii) We will use the humanized version of the multiple marker panel to search for new treatments that may be personalized based on the multiple markers