We have a 2 year post-doctoral position available to study the role of specific proteins involved in congenital anomalies of the kidney and the urinary tract (CAKUT)1.
Clinical management of CAKUT is severely hampered by the lack of tools to predict and manage its progression towards kidney failure and its complications. In the past we have identified a number of urinary markers of obstructive CAKUTs that allowed prediction of future renal function2,3 that could lead to improved management of the disease. In more recent projects we have identified and confirmed a number of proteins in amniotic fluid that were strongly associated to severe CAKUT phenotypes suggesting their involvement of CAKUT.
The main goal of this post-doctoral research is to investigate the role of these proteins in the development of CAKUT using in-vitro, ex-vivo (organoids) and in-vivo (Zebrafish) models. The candidate will develop and manage these approaches/models in the laboratory. Furthermore the post-doctoral fellow will be involved in the further downstream analysis of the omics data to determine other potential candidates and pathway for drug repurposing. All the necessary tools (bioinformatics, molecular biology, imaging, zebrafish facility …) are available within the institute.
The ideal candidate would already have experience with studies in kidney pathophysiology. Experience with zebrafish, in-vitro and ex-vivo models in the field of CAKUT would be an advantage. The position must be filled before October 2017.
For further information or application please contact Dr Joost Schanstra at email@example.com with a motivation letter, a CV, at least one reference letter and earliest availability date to pick up the position.
1Nicolaou, N., et al., Nat Rev Nephrol 11(12):720-31
2Decramer, S., et al., Nat Med, 2006. 12(4): p. 398-400
3Klein, J., et al., Science Translational Medicine, 2013. 5(198)