Due the the progression of the coronavirus in France in the middle of March 2020, the RF-lab, naturally, also had to close its doors to participate to the effort of reducing the impact of the virus.   Day-2: Sunday March 15 – the first signs Mail from Inserm’s director: “We will be closing the labs tomorrow”. A WhatsApp group of the RF-lab was generated to keep contact.   Day-1: Monday March 16 – the day before Didi and Joost were allowed to come to the lab to prepare the lockdown and bring the different “tools”  (computers and stuff) to the home of the lab members.Read More →

Congratulations Ana for winning the best poster prize during the last annual CaReSyAn meeting and Cardiorenal Winter School. Ana’s reaction to winning the prize “Last week I had the opportunity to present at the CaReSyAn annual meeting and Cardiorenal Winter School of the graduate schools SFB TRR219 IRTG & Marie-Curie ITNs CaReSyAn and INTRICARE in Frankfurt. It was a great experience and I was luckily awarded with the prize for best scientific poster presentation, which I would like to share with my supervisors Julie Klein and Joost Schanstra for all their support. But most importantly, we had the chance to listen to very interesting topics aboutRead More →

One of the aims of the RF-lab is to make the general public aware of kidney disease and its complications. Therefore every we participate to events for the general public to increase awareness. This year again we showed up at the Researchers’s night: a great succes with many children/adults visiting the stand and learning and playing how the kidney works. Follow us on twitter: RFLab.tlse.      

It has finally happened. The famous RF-lab cleaning day ! Before:                   After !                         Some prehistorical findings:                   These are CDs kids!!…what ?????   And the lab rules after cleaning up, very important !!!!  

-Cytosolic PLA2-targeting drug reduces vascular calcification-  Endothelial dysfunction is a hallmark of cardiovascular disease (CVD) that ultimately leads to thrombosis and vascular occlusion. Despite being a leading cause of death worldwide, there has been a paucity of promising drug targets to prevent and/or minimize CVD. Joost Schanstra, Trang Luong, Manousos Makridakis, Sophie Van Linthout and colleagues evaluated the arterial proteome of patients with advanced and early CVD to identify a CVD-associated signature with potential to be targeted by bioactive small molecules. Of the candidate drugs, cytosolic phospholipase A2 (cPLA2) inhibitor AACOCF3 was a top candidate to reverse in-silico the proteomic signature of advanced CVD, asRead More →

Together with partners from Spain, Germany and the CEA in Paris, the RF-lab and the Toulouse hospital obtained a European grant for joint-research for implementation of Personalized Medicine in acute kidney disease. In our lab the project is coordinated by Stanislas Faguer, Julie Klein and Joost Schanstra.   The project includes research involving >1600 patients scheduled for cardiac surgery and at risk for acute kidney injury and development of novel treatments based on systems biology.   Here the official announcement of the study: Acute kidney injury (AKI) kills 2 million people every year. In AKI, kidney function fails suddenly and may later recover spontaneously. HoweverRead More →

This year our research center celebrated Halloween with the Halloween cake contest. Our team was again represented by Ophélie Lescat who gave us, again (!!), a victory. Bravo Ophélie !!!   Here the picture of the winner with the first prize in hand…