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This year again the RF-lab was present at the kidney-week, this time held in New Orleans. We presented two posters and one oral presentation. Julie Klein gave an excellent oral presentation during the Saturday afternoon (4/11) session “Pediatric Nephrology and Developmental Biology” on our work on amniotic fluid peptides predictive of post-natal renal function in fetuses with CAKUT. The importance of the work was exemplified by a tweet from one of the spectators and the many interesting questions. We also presented two posters: Valerie Brunchault presented 1 poster entitled “A first assessment of urinary peptide biomarkers predictive of cardiovascular complications in children with chronic kidney disease” which attracted a lotRead More →

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Yet another PhD student got his PhD in the RF-lab. Daniel Borras defended with virtuosity his thesis entitled “ The use of sequencing technologies for the better understanding of molecular determinants in renal diseases”. The thesis was carried out in close collaboration with Prof Bart Janssen from GenomeScan in Leiden in the Netherlands and in the context of the ITN network iMODE-CKD (“Clinical and system –omics for the identification of the Molecular DEterminants of established Chronic Kidney Disease”). Congrats Dani and good luck with your postdoctoral research!           ps, excellent Catalan food…!!!!!

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The RF lab participated at the science fair in Toulouse called “la nuit des chercheurs” = “the night of the researchers”. We aimed to entertain the younger public. Finally we had ~130 children visiting our stand!! …and we are very proud of that!! They learned where their kidneys were, how much blood is filtered every day, how the kidney separates the useful from the useless, looked at kidneys under a microscope and checked whether a urine sample came from a person with kidney disease.     Check out the movie: [embedyt] https://www.youtube.com/watch?v=JOc2YaG-PAw[/embedyt]   In French the children were attracted by the following text Docteur Pipi etRead More →

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Wednesday September 20, 2017 was the big day for Koryun. He brilliantly defended his thesis and was awarded the highest academic degree! Thanks for everything. We wish you all the best for the future Koryun and hope to see you soon!!    

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Summer 2017 has brought us again the annual RF-lab BBQ! On a warm but not so sunny day in July 2017 we  enjoyed the company from our lab-fellows and friends. Having a drink, some local food and of course excellent meat grilled on the barbeque!     This year Koryun one of our PhD students took care of the meat and the preparation….excellent, thank you Koryun !    So who will do this next year ….?      

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Toulouse, Friday 22nd September 2017 Organised in collaboration with ERA-EDTA and ESAO  “Prevention of vascular and kidney disease now, to save lives and costs in the future.”   Register now to the EUTox CME Course! Chronic renal disease (CKD) is a frequent disease in western countries. The reduced glomerular filtration rate in the advanced stages of CKD leads to plasma accumulation of toxic retention solutes including proteins. It has been hypothesized that these changes may, at least in part, be responsible for CKD-associated morbidity and mortality. Recent reports indicate that a large proportion of renal, cardiovascular and/or cerebrovascular diseases are based on a common background,Read More →

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We have a 2 year post-doctoral position available to study the role of specific proteins involved in congenital anomalies of the kidney and the urinary tract (CAKUT)1.   Clinical management of CAKUT is severely hampered by the lack of tools to predict and manage its progression towards kidney failure and its complications. In the past we have identified a number of urinary markers of obstructive CAKUTs that allowed prediction of future renal function2,3 that could lead to improved management of the disease. In more recent projects we have identified and confirmed a number of proteins in amniotic fluid that were strongly associated to severe CAKUTRead More →

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For the 6th consecutive year, on 19 May, Inserm has opened the doors of its laboratories to students from primary to high school, in several cities in France. The operation “Destination Labo” gives annual opportunity for school to come discover the world of biomedical research and exchange with researchers, engineers and technicians on their job in order to refine their career plans and encourage vocations. A window on the usually impenetrable places! In Toulouse, in collaboration with the Academy of Toulouse, the Institute of metabolic and cardiovascular diseases (INSERM UMR / UPS 1048 – I2MC) hosted one classe. The program was made of mini-lectures, directRead More →

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The RF-lab has participated to the final EURenOmics meeting in Berlin. Bénédicte gave an excellent presentation on the identification of amniotic fluid peptides able to predict post-natal renal function in patients with congenital anomalies of the kidney and the urinary tract (CAKUT). We believe that this work can have significant impact on the clinical management of this disease.

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  We got 3 year financial support from the French Medical Research Foundation “La FRM”. The help of the FRM is greatly acknowledged and will help use to expand significantly our research in the field of developmental nephropathies and contribute to the improved clinical management of children with such diseases.   Here is the abstract of the project: CAKUT (congenital anomalies of the kidney and the urinary tract) are the leading cause of end stage renal disease in children. Clinical management of CAKUT is severely hampered by the lack of tools to predict and manage its progression towards kidney failure and its complications. Here weRead More →